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Tweetdeck is an Adobe Air desktop application that brings Twitter to the desktop of Mac and PC in the most readable format yet.

Tweetdeck uses column layouts to arrange Tweets however you like. The default columns are All Tweets, Replies, Direct, but Tweetdeck’s functionality allows you to add/remove columns and custom ‘build’ your own columns – even group certain Twitter users to their own column.

It also gives you on screen notifications of new Tweets and incorporates an optional column to display a Twitscoop keyword cloud to show you what the biggest keywords are on Twitter right now.

The interface is sleek and Web 2.0 style. Columns can be resized or rearranged by dragging. You can also Tweet directly from the application of course, and it has built in shorten url functionality and Twitpic.

The only thing I would say it lacks is highlighting of new Tweets, which I greatly appreciate from Socialthing.